[Download] "Clinical Evidence of Autologous Graft Versus Tumor Effect (Report)" by American Journal of Immunology * eBook PDF Kindle ePub Free
eBook details
- Title: Clinical Evidence of Autologous Graft Versus Tumor Effect (Report)
- Author : American Journal of Immunology
- Release Date : January 01, 2009
- Genre: Life Sciences,Books,Science & Nature,
- Pages : * pages
- Size : 85 KB
Description
INTRODUCTION The adoptive transfer of donor immune effectors cells in Allogeneic Hematopoietic Stem Cell Transplantation (Allo-HSCT) has revived the interest in cellular immunotherapy of cancer as a potentially curative treatment modality[1]. The anti-tumor activity observed in the Allo-HSCT has been ascribed to the allogeneic Graft-Versus-Tumor (GVT) effect due to the infusion of alloreactive lymphocytes. The source of alloreactive lymphocytes is the donor stem cell inoculum of the allograft. In contrast, the high relapse rates observed after Autologous Hematopoietic Stem Cell Transplantation (AHSCT) are presumed in part due to the lack of GVT[2]. In this review, I will present clinical evidence of an autologous GVT mediated by the infusion of autologous lymphocytes.
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